Fig. 1: Synthesis chiral chiral group 14 element center.

a Chiral carbon centers can be readily synthesized asymmetrically, primarily due to the wide availability of suitable starting materials. b Chiral silicon centers can be prepared by combining stepwise chloride displacement with desymmetrization strategies. c The reported synthetic routes for germanium centers substituted with four distinct carbon groups have thus far been limited. d A rapid synthesis approach for chiral germanium centers has been developed by strategically decoupling reactivity and selectivity issues. e Deborylative alkylation of poly-germanium chlorides, followed by copper-catalyzed enantioselective desymmetrization of prochiral 1,3-diols, has been successfully achieved. This methodology provides efficient access to synthetic intermediates and chiral germanium products characterized by high functional group tolerance and excellent enantioselectivity.