Fig. 1: Disease progression following HPAI A(H5N1) infection. | Nature Communications

Fig. 1: Disease progression following HPAI A(H5N1) infection.

From: Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease

Fig. 1

Six-week-old C57BL/6J mice (n = 10 per group) were inoculated via either intranasal or orogastric routes with 105 TCID50 of either A/bovine/OH/B24OSU-342/2024, A/mountain lion/MT/1/2024), A/mink/Spain/3691-8_22VIR10586-10/2022, or A/Vietnam/1203/04. Mice (n = 6) in each group were monitored for clinical signs and survival. A Weight loss following intranasal inoculation. B Weight loss following orogastric inoculation. C Survival following intranasal inoculation. Survival proportions were calculated using the log-rank test with Bonferroni correction for multiple comparisons. ns p > 0.05, *p < 0.05, **p < 0.01, ****p < 0.0001. D Survival following orogastric inoculation. Note, animal group sizes change over time due to animals succumbing to infection. A, B Data shown as mean plus standard error of the mean.

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