Fig. 2: Infectious virus titers in organs following HPAI A(H5N1) infection. | Nature Communications

Fig. 2: Infectious virus titers in organs following HPAI A(H5N1) infection.

From: Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease

Fig. 2

Six-week-old C57BL/6J mice were inoculated with 105 TCID50 of A/bovine/OH/B24OSU-342/2024, A/mountain lion/MT/1/2024), A/mink/Spain/3691-8_22VIR10586-10/2022, or A/Vietnam/1203/2004. On day 4 post inoculation, 4 animals from each group were euthanized to determine virus titers in organs (lung, liver, brain) and blood. A–D Intranasally inoculated mice. E–H Orogastric inoculated mice. Dashed line indicates limit of detection. Statistical analyses were performed using one-way ANOVA with Tukey’s multiple comparison. ns p > 0.05, *p < 0.05, **p < 0.01, ****p < 0.0001. Comparisons with p values > 0.05 were not displayed. Violin plots show interquartile range, median and density curve.

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