Fig. 3: Histologic lesions and antigen expression following HPAI A(H5N1) intranasal inoculation. | Nature Communications

Fig. 3: Histologic lesions and antigen expression following HPAI A(H5N1) intranasal inoculation.

From: Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease

Fig. 3

Six-week-old C57BL/6J mice were inoculated intranasally with 105 TCID50 of A/bovine/OH/B24OSU-342/2024, A/mountain lion/MT/1/2024), A/mink/Spain/3691-8_22VIR10586-10/2022, or A/Vietnam/1203/2004. A subset of animals (n = 4) was euthanized at day 4 post inoculation for histopathologic evaluation. Representative sections from each group shown. A, E, I, M, Q Hematoxylin & eosin stain of brain sections. C, G, K, O, S Hematoxylin & eosin stain of lung sections. B, F, J, N, R Immunohistochemistry staining of brain sections for Influenza A virus nucleoprotein antigen; D, H, L, P, T Immunohistochemistry staining of lung sections for Influenza A virus nucleoprotein.

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