Fig. 8: Brain histologic lesions and antigen expression following HPAI A(H5N1) inoculation. | Nature Communications

Fig. 8: Brain histologic lesions and antigen expression following HPAI A(H5N1) inoculation.

From: Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease

Fig. 8

Six-week-old C57BL/6J or BALB/C mice were inoculated intranasally with DMEM (mock) or 103 TCID50 of A/bovine/OH/B24OSU-342/2024. A subset of animals from each group (n = 4) was euthanized at day 2 or 4 post infection for brain histopathologic evaluation. Representative sections from each group shown. A–F Hematoxylin & eosin stain. G–L Immunohistochemistry staining for Influenza A virus nucleoprotein antigen. Magnification ×100, bar 100 µm.

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