Fig. 2: Summary of molecular alterations. | Nature Communications

Fig. 2: Summary of molecular alterations.

From: A macrophage-predominant immunosuppressive microenvironment and therapeutic vulnerabilities in advanced salivary gland cancer

Fig. 2

A Oncoprint with molecular alterations in a set of selected genes commonly affected in SGC (n = 104). On the left, the percentage of samples with one or more alterations in each listed gene is shown. The top bar shows the total number of alterations in the specific sample. The heatmap at the bottom represents the expression of MYB and MYBL1 genes. B Co-barplot with most common SNVs in ACC and non-ACC. TP53 alterations are the only SNVs significantly enriched in non-ACC. C Tumor mutational burden was significantly higher in non-ACC (n = 43, median = 2.3, iqr = 2.5, max = 8.3, min = 0.03) compared to ACC samples (n = 60, median = 0.82, iqr = 0.54, max = 4.7, min = 0.17) (Wilcoxon test, two-sided).

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