Fig. 3: Substrate scope of C(sp3)–H oxygenation. | Nature Communications

Fig. 3: Substrate scope of C(sp3)–H oxygenation.

From: Copper-catalyzed C(sp3)−H amination and etherification of unactivated hydrocarbons via photoelectrochemical pathway

Fig. 3

Reaction conditions: undivided cell, graphite rod anode (φ = 6 mm), platinum plate cathode (15 × 10 × 0.2 mm3), aryl alcohol (0.3 mmol, 1.0 equiv.), hydrocarbon (3.0 mmol, 10.0 equiv.), 9-phenylacridine (0.03 mmol, 10 mol%), (CuOTf)2·C6H6 (0.06 mmol, 20 mol%), 4,7-diphenyl-1,1-phenanthroline L2 (0.06 mmol, 20 mol%), K2CO3 (0.3 mmol, 1.0 equiv.), nBu4NPF6 (0.60 mmol, 2.0 equiv., 0.2 M) and anhydrous MeCN:DCE = 1:1 (v/v, 3.0 mL), constant current = 3 mA, 390 nm LEDs (10 W) under N2 atmosphere at room temperature for 10 h (3.7 F·mol–1). Yields of isolated products after chromatographic purification. Regioselectivity (r.r.) and diastereomeric ratio (d.r.) were determined by 1H NMR analysis. aThe reaction was performed on a 6.0 mmol scale.

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