Fig. 2: The characterization of nanovaccine and hydrogel system. | Nature Communications

Fig. 2: The characterization of nanovaccine and hydrogel system.

From: Neoantigens combined with in situ cancer vaccination induce personalized immunity and reshape the tumor microenvironment

Fig. 2

a The preparation process of O-MRDE/Mn. b Transmission electron microscope (TEM) images of BSA/Mn, DE, and O-MRDE/Mn. c Flow cytometry detected proteins that are characteristic of DE and O-MRDE/Mn. d Zeta potentials and size distributions. e Hemolysis assay for Mel, α-Mel, α-Mel-OVA, and O-MRDE. f The preparation and ROS responsiveness processes of O-MRDE/Mn+CXCL10@Gel. g Representative morphology and SEM image of hydrogel scaffold loaded with O-MRDE/Mn and CXCL10. h, i Oscillatory strain sweep (h) and cycling strain sweeps (i) of hydrogels. j-l Mass remaining of hydrogels (j) and accumulative release profiles of CXCL10 (k) and Mn (l) from hydrogels under PBS and H2O2 (1 mM) conditions. m Chemotactic migration assay of T cells when treated with different doses of CXCL10. Data in d, e, j–m were mean ± SD (n  =  3 independent experiments). Source data are provided as a Source Data file.

Back to article page