Fig. 5: O-MRDE/Mn improves immune cell infiltration and inhibits tumor growth and spread. | Nature Communications

Fig. 5: O-MRDE/Mn improves immune cell infiltration and inhibits tumor growth and spread.

From: Neoantigens combined with in situ cancer vaccination induce personalized immunity and reshape the tumor microenvironment

Fig. 5

a Levels of antigen SIINFEKL-presented DCs (25d1.16+CD11c+) in tumor. b Levels of SIINFEKL-specific CD8+ T cells from peripheral blood. c, d Levels of IFN-γ+ T cells (CD8+IFN-γ+) (c), and GrB+ T cells (CD8+GrB+) (d) in spleen. e Levels of CD107a+CD8+ T cells in tumor. f Diagrammatic representation of remodeling immunosuppressive TME. g Quantitative analysis of M1/M2 TAMs in tumor. h–l Quantitative analysis of immunofluorescence data of Ki67+ cells (h), CD31+ cells (i), CD44+ cells (j), CD8+ T cells (k) and Tregs (Foxp3+CD4+) (l) in tumors. m Quantitative analysis of CD8+ T cells/Tregs in tumor tissues. n Number of CD3+CD8+ T cells per mg of tumor tissue. o Quantitative analysis of Th1 cells in tumor tissues. p, q Quantitative analysis of immunofluorescence data of Th1 cells (T-bet+CD4+) (p), and Th2 cells (GATA-3+CD4+) (q) in tumor tissues. Data were mean ± SD (n = 6 mice per group). The significance between each of the multiple groups in (a–e), (g–q) was calculated using one-way ANOVA. Source data are provided as a Source Data file.

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