Fig. 2: Design and synthesis of α-hydroxycarboxylic acid derivatives. | Nature Communications

Fig. 2: Design and synthesis of α-hydroxycarboxylic acid derivatives.

From: Substrate-based discovery of α-hydroxycarboxylic acid derivatives as potential herbicides targeting dihydroxyacid dehydratase

Fig. 2

a Design strategy for compounds I-6 and the model of the substrate (2,3-dihydroxy-3-methylbutanoic acid) and I-6 docked into AtDHAD. Light blue indicates the substrate with AtDHAD, and the light coffee color indicates I-6 with AtDHAD. b Kd value of compound I-6 binding to AtDHAD and the inhibitory effect of 25 and 50 μg/mL I-6 on A. thaliana germination. The data are presented as the mean ± SD. c The general synthetic scheme for the title compounds. d Cs2CO3-initiated α-C (sp3)-H hydroxylation of carbonyl derivatives I-5a − I-5m and target compounds I-6a − I-6n. The yields shown are for the isolated products. The crystal structures of compounds I-5b and I-6c are shown. Source data are provided as a Source Data file.

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