Fig. 2: Blood flow in the HSPC niche decreases during aging. | Nature Communications

Fig. 2: Blood flow in the HSPC niche decreases during aging.

From: Decreased non-neurogenic acetylcholine in bone marrow triggers age-related defective stem/progenitor cell homing

Fig. 2

a, b Intravital BM imaging of Evi1high HSPCs and adjacent blood vessels in young (a) or old (b) Evi1-GFP mice before (left) and after (right) 3D rendering. Arrowhead indicates Evi1high HSPC. Bar = 10 μm. c Percentage of intrasinusoidal volume in BM (young, n = 15; middle-aged, n = 12, old, n = 13 biological replicates). d, e Hemodynamic parameters of artery (d) or sinusoid (e) in BM of young (artery, n = 11; sinusoid, n = 15 biological replicates), middle-aged (artery, n = 13; sinusoid, n = 12 biological replicates), and old mice (artery, n = 6; sinusoid, n = 13 biological replicates). Values are mean ± SD. One-way ANOVA with Tukey–Kramer test. *p < 0.05. Source data are provided with this paper.

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