Fig. 3: Fusion gene and TP53 mutation status determine sarcoma biology and microenvironment.
From: Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas
a Heatmap view of mouse sarcomas, quantified for six morphological and based on H&E staining and integrated expression scores for 10 antigens determined by immunohistochemistry. Asymmetric color scale for combined visualization of low (CD45, CD3, cCas3) and high-scoring antigens. Quantification by blinded expert pathology review. b Pearson correlation matrix based on data from a. Insignificant p values (≥0.05) are indicated. Blue indicates positive, red indicates negative correlation, and point size reflects effect size. c, d IHC scores of Ki-67 and CD45 from a visualized as boxplots ordered by median from low to high. Boxplots display individual values, median, and interquartile range (IQR). Whiskers extend to the most extreme data points within 1.5 times the IQR from the lower and upper quartiles. P values were determined by unpaired two-sided Wilcoxon tests and corrected for multiple testing by Bonferroni–Holm method. n ≥ 3 tumors per group. Source data are provided as a Source data file.
