Fig. 3: Muscle Rev-erb is required for the timing effects of exercise training on weight control, contractile performance, and glucose tolerance.
From: Muscle Rev-erb controls time-dependent adaptations to chronic exercise in mice
a Body weight (n = 9 mice for KO EX_AM, n = 10 mice for the other groups). *p = 0.0473 and 0.042 for WT EX_AM vs. WT EX_PM with 2-way repeated-measure ANOVA and Tukey test. WT, Rev-erbfloxed mice. b, c Forelimb grip strength test and wire hang test at 6 months old (n = 9 mice for KO EX_AM, n = 10 mice for the other groups). *p = 0.0318 (ZT23-1) and 0.0332 (ZT11-13) for grip strength, 0.0409 (ZT23-1) and 0.0346 (ZT11-13) for wire hang, by 2-way ANOVA and Tukey test. d Treadmill distance at 7 months old (n = 9 mice for KO EX_AM, n = 10 mice for the other groups). *p = 0.0001 (EX-AM vs. EX-PM at ZT23-1) and 0.0297 (ZT23-1 vs. ZT11-13 for WT EX_AM) by 2-way ANOVA and Tukey test. e GTT at ZT 23-1 at 8 months old (n = 9 mice for KO EX_AM, n = 10 mice for the other groups). Data are mean ± SD. *p = 0.0414, 0.0486 and 0.0236 for WT_EX_AM vs. WT_EX_PM with 2-way repeated-measure ANOVA and Holm-Sidak test. f Area under the curve (AUC) in GTT. *p = 0.0149 with 1-way ANOVA and Tukey test. g, h Dorsi flexor tetanic torque at 9 months old (n = 9 mice for KO EX_AM, n = 10 mice for the other groups). *p = 0.0255 (ZT23-1) and 0.0193 (ZT11-13) by 1-way ANOVA and Tukey test. i–l Fatigue analysis at 9 months old at ZT23-1 (n = 8 mice for WT, n = 6 mice for KO) or ZT11-13 (n = 8 mice for WT EX_AM, n = 7 mice for WT EX_PM, n = 5 for KO EX_AM, n = 6 mice or KO EX_PM). *p = 0.0053 (ZT23-1) and 0.0202 (ZT11-13) by 1-way ANOVA and Tukey test. Data are mean ± SEM unless otherwise specified. ns, not significant.
