Fig. 2: MIND connectivity across the HD time course.
From: Cell-specific mechanisms drive connectivity across the time course of Huntington’s disease
a Group-level cortical similarity matrices, each column and row represents a brain region of interest, termed a ‘node’ and each value in the matrix represents the ‘connection’ between two brain regions. The node strength represents the sum of all values for a given brain region, whereas the connection strength represents the magnitude of the connection between two brain regions. b Nodal strength for the differences between pwHD and controls across ROIs. In early preHD there are increases in connectivity predominantly occipital and frontal areas while in late preHD these differences attenuate. Finally, in mHD participants there are clear decreases in connectivity affecting also occipital and frontal areas. c Density plots representing the differences between pwHD and controls. Positive values in early preHD indicate increases in connectivity in pwHD compared with controls. These differences are predominantly negative in late preHD although most observations are around the null value. Finally, mHD participants have evident decreases in connectivity compared to controls. d Violin plots depicting ROIs showing significant differences at the uncorrected level in early preHD and late preHD. In mHD, for visualization purposes, only the top five ROIs with larger effect sizes were shown, all of them significant following non-parametric permutation two-tailed tests, FDR correction at a P < 0.05. e Circular graphs depicting significant networks (network-based statistics, non-parametric permutation two-tailed t-tests FDR correction at a P < 0.05) in early preHD (early preHD > controls), late preHD (no significant results) and mHD (mHD < controls), five connections in the occipital lobe were significantly higher in mHD compared to controls and are represented in Fig. S3. f Axial view showing significant connections, (network-based statistics, non-parametric permutation two-tailed t-tests FDR correction at a P < 0.05) spheres indicate brain regions; lines indicate connections significantly different from controls. Source data are provided as a Source Data file. FDR false discovery rate, HD Huntington’s disease, HDGEC Huntington’s disease gene expansion carrier, mHD manifest Huntington’s disease, MIND morphometric inverse divergence, NBS network-based statistic, pwHD people with Huntington’s disease, preHD premanifest Huntington’s disease, ROI region of interest.
