Fig. 3: MIND connectivity and plasma NfL correlations.
From: Cell-specific mechanisms drive connectivity across the time course of Huntington’s disease
a There are positive correlations between plasma NfL and nodal strength in early preHD. During late preHD stages the direction of the correlation coefficients starts to change being again clearly negative in mHD stages. b Circular graphs showing significant associations (network-based statistics, non-parametric permutation two-tailed tests FDR correction at a P < 0.05)between connectivity and plasma NfL in early HD (no significant results), late preHD, and mHD. c Axial view showing significant connections (network-based statistics, non-parametric permutation two-tailed t-tests FDR correction at a P < 0.05), spheres indicate brain regions; lines indicate connections significantly correlated with plasma NfL. Source data are provided as a Source Data file. HD Huntington’s disease, mHD manifest Huntington’s disease, MIND morphometric inverse divergence, NfL neurofilament light protein, NBS network-based statistics, preHD premanifest Huntington’s disease, ROI region of interest.
