Fig. 4: Disease epicentre mapping.
From: Cell-specific mechanisms drive connectivity across the time course of Huntington’s disease
Cortico-cortical functional (a) and structural (c) connectivity matrices in healthy controls. The colored areas in the brain surfaces depict regions (epicentres) whose connectivity profiles are significantly correlated with MIND nodal strength in each HD cohort. Only the paracentral and posterior cingulate gyri in late preHD were disease epicentres in the structural connectivity analysis (non-parametric spin permutation test, two-tailed, FDR correction at a P < 0.05, DF = 66). In (b, d) the matrices represent the subcortico-cortical functional (b) and structural (d) connectivity profiles, not being significantly associated with connectivity. Statistical significance was assessed through FDR-corrected spin permutation tests. Source data are provided as a Source Data file. DF degrees if freedom, HD Huntington’s disease, FDR false discovery rate, MIND morphometric inverse divergence, preHD premanifest Huntington’s disease.
