Fig. 5: Contributions of different organizational principles to MIND nodal strength.
From: Cell-specific mechanisms drive connectivity across the time course of Huntington’s disease
Brain region by brain region matrices were constructed for each organizational principle using data from healthy controls. These were spatially correlated with nodal strength representing the differences in connectivity across the same regions between pwHD and controls (Cohen’s d) in each cohort. Values and colors (yellow: higher, violet: lower) in each cell represent Spearman correlation coefficients. Statistical significance was assessed through non-parametric FDR-corrected spin permutation tests, two-tailed, DF = 66. Light blue asterisks indicate statistically significant results (Pspin < 0.05). Source data are provided as a Source Data file. DF degrees of freedom, FDG-PET [F18]-fluorodeoxyglucose positron emission tomography, FDR false discovery rate, MEG magnetoencephalography, MIND Morphometric Inverse Divergence, pwHD people with Huntington’s disease, preHD premanifest Huntington’s disease, rsfMRI resting-state functional MRI.
