Fig. 7: Global and layer-specific neurotransmitter distribution and nodal strength for cortical connectivity networks in Huntington’s disease.
From: Cell-specific mechanisms drive connectivity across the time course of Huntington’s disease
A multilinear model was used to determine the association between the distribution of the different neurotransmitter systems and node strength across the lifespan of HD. a illustrates how neurotransmitter system distributions map onto nodal strength across the different HD cohorts (total R2adj). Only significant results (*) assessed through FDR-corrected spin permutation tests, one-sided, N = 68 regions are represented in a, b (PET) and c, d (autoradiography). The dominance analysis in (b) distributes the fit of the model across each input variables showing the relative contribution of each variable. In (c), the total R2adj for layer-specific autoradiography results for nodal strength in early preHD are depicted, while (d), shows the relative contribution of each neurotransmitter system. Remaining autoradiography analyses were not statistically significant in any cohort. Source data are provided as a Source Data file. FDR false discovery rate, HD Huntington’s disease, mHD manifest Huntington’s disease, MIND morphometric inverse divergence, preHD premanifest Huntington’s disease. *Pspin < 0.05; PET positron emission tomography.
