Fig. 8: Cynomolgus monkey PK and population PK (PopPK) modeling with human scaling and simulation.
From: Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis
a Mean ( ± SD) ART5803 overlay of serum and CSF concentrations in cynomolgus monkeys following a single IV dose at 100 and 1000 mg/kg (n = 3 each dose). SD = standard deviation, CSF = cerebrospinal fluid, BLQ = below limit of quantification. b Simulated ART5803 concentrations in human CSF via IV weekly dosing based on cynomolgus monkey PopPK modeling. The model-predicted CSF concentration–time profiles after IV administration are depicted (0.1 – 100 mg/kg every 7 days). Approximate doses greater than 40, 60 and 100 mg/kg were required to achieve target concentration 0.6 – 2.5 µg/mL in CSF (the top light green band). Source data are provided as a Source Data file.
