Fig. 1: Sequence analysis of the γ-secretase substrate cleavage region. | Nature Communications

Fig. 1: Sequence analysis of the γ-secretase substrate cleavage region.

From: Charting γ-secretase substrates by explainable AI

Fig. 1

a Overview of γ-secretase cleavage and functions (Created in BioRender. Breimann, S. (2025) https://BioRender.com/bzswlhf). b Sequence logo of the cleavage region of 23 substrates with known cleavage sites. Shown are five positions on the N-terminal (P1–P5) and C-terminal side (P1’–P5’) of the initial cleavage site indicated by ↓. Amino acids are colored according to their physicochemical properties: hydrophobic (black), neutral (green), hydrophilic (blue). c, d Sequence logos of the last ten amino acids of the TMD-C and the first four amino acids of the JMD-C for the SUBEXPERT (c) and NONSUB (d) datasets. See Methods (“Sequence parts of transmembrane proteins”, “Datasets”, and “Sequence logos”) for further details. Source data are provided as a Source Data file.

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