Table 2 Sensitivity and specificity of each rule to identify children who were recommended treatment under the comprehensive rule
From: Personalized azithromycin treatment rules for children with watery diarrhea using machine learning
Rule | Day 3 diarrhea | Day 90 re-hospitalization/death | Change in linear growth | |||
|---|---|---|---|---|---|---|
Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | |
Shigella | 53.4% (51.1%, 55.9%) | 94.5% (93.8%, 95.1%) | 14.8% (13.4%, 16.3%) | 94.8% (94.1%, 95.4%) | 21.5% (19.9%, 23.2%) | 91.0% (90.1%, 91.8%) |
Rotavirus | 32.1% (29.9%, 34.3%) | 77.0% (75.8%, 78.2%) | 21.4% (19.8%, 23.1%) | 89.1% (88.2%, 90.0%) | 20.4% (18.8%, 22.1%) | 90.3% (89.4%, 91.1%) |
Pathogen Quantities | 66.7% (64.3%, 68.8%) | 91.4% (90.6%, 92.2%) | 40.3% (38.4%, 42.3%) | 81.2% (80.0%, 82.3%) | 42.6% (40.6%, 44.6%) | 80.3% (79.1%, 81.5%) |
Symptoms | 72.1% (70.0%, 74.2%) | 89.7% (88.8%, 90.5%) | 27.2% (25.4%, 29.0%) | 88.1% (87.1%, 89.0%) | 40.6% (38.6%, 42.7%) | 76.9% (75.6%, 78.1%) |
Pathogen + Symptoms | 75.9% (73.8%, 77.9%) | 91.9% (91.1%, 92.6%) | 44.7% (42.8%, 46.7%) | 84.5% (53.3%, 85.5%) | 54.4% (52.4%, 56.5%) | 80.7% (79.5%, 81.8%) |
Host | 31.2% (29.1%, 33.5%) | 86.9% (85.9%, 87.8%) | 74.4% (72.7%, 76.1%) | 78.0% (76.7%, 79.2%) | 55.0% (53.0%, 57.1%) | 81.7% (80.6%, 82.8%) |
Host + Symptoms | 43.9% (41.6%, 46.3%) | 86.8% (85.9%, 87.8%) | 77.8% (76.0%, 79.3%) | 80.8% (79.6%, 82.0%) | 67.1% (65.1%, 69.0%) | 80.5% (79.3%, 81.7%) |
