Fig. 3: Disorder-specific two-year follow-up (“_T2) and two- to three-year follow-up change (“_T2_T3”) scores linked by CCA to sex, PhenoAge, as well as self-reported and hormonally based indices of adrenarche and gonadarche in the ABCD sample.

Panel A The horizontal graph shows the partial correlation coefficients describing the relationship between the observed disorder-specific scores and the predicted value of their corresponding canonical variate across all test CCA folds from the cross-validation procedure. Panel B The horizontal graph shows the partial correlation coefficients describing the relationship between the observed values of the sex (female = 1, male = 0), PhenoAge, as well as self-reported and hormonally based indices of adrenarche and gonadarche with the predicted value of their corresponding canonical variate across all test CCA folds from the cross-validation procedure. The shaded areas with non-zero color coding (see “Loadings” legend) in panels A and B correspond to robust correlations based on 99% CIs from the cross-validation procedure. The violin plots in panels A and B depict the distribution of partial correlation coefficients across the 100,000 bootstrap samples from the cross-validation procedure. Panel C contains the scatter plot describing the linear relationship between the two CCA variates pictured in panels A and B. CCA = canonical correlation analysis. ADHD = attention deficit hyperactivity disorder. Anx anxiety, CD conduct disorder, Dep depression, OCD obsessive-compulsive disorder. ODD oppositional defiant disorder, PTSD post-traumatic stress disorder, SCT slow cognitive tempo, SOM somatic disorder, SR self-report, H hormonally based.