Fig. 8: Top-down view of the DNA cleft occupied by delafloxacin in the 2.0 Å V−18 X-ray crystal structure (PDB ID: 8QMB). | Nature Communications

Fig. 8: Top-down view of the DNA cleft occupied by delafloxacin in the 2.0 Å V−18 X-ray crystal structure (PDB ID: 8QMB).

From: Structural basis of topoisomerase targeting by delafloxacin

Fig. 8

The ParC backbone is in blue, the ParE backbone is in yellow, DNA backbone is in light blue, the intercalated drug molecule is in red, magnesium ions are in purple, and the active site tyrosine (Y118) and arginine residues (R117) are in orange, DNA bases and sugars are in silver, active site magnesium-coordinating residues are in purple. The positions of ParC S79 and D83 residues responsible for quinolone resistance upon mutation are indicated by arrows.

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