Fig. 2: Depletion of blood ApoM-S1P complex impairs SVZ neurogenesis and olfaction. | Nature Communications

Fig. 2: Depletion of blood ApoM-S1P complex impairs SVZ neurogenesis and olfaction.

From: HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease

Fig. 2

a Representative immunofluorescence images (left) and quantification of BrdU+ newly formed neurons in the GCL (right upper) and GL (right lower) in the OB (n  =  6/group). Scale bars, 30 μm. b Representative immunofluorescence images and quantification of CB+ cells, CR+ cells, TH+ cells in GL (n  =  6/group). Scale bars, 30 μm. c, d The results of olfactory habituation–dishabituation test for both urine (c) and peanut butter (d) scents (WT, n = 16; Apom-/-, n = 19). e The results of olfactory avoidance test (WT, n = 18; Apom-/-, n = 19). f–i The results of the olfactory discrimination test 1 (f), test 2 (g), test 3 (h), and calculated a discrimination index of the data points shown in f (i) (n  =  18/group). j The latency to locate a buried food reward (WT, n = 14; Apom-/-, n = 13). a, b, i, j Two-tailed student’s t test. c–h Two-way ANOVA for repeated measures. All error bars indicate s.e.m. All data analysis was done at 4-month-old mice. Source data are provided as a Source Data file.

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