Fig. 6: Decrease of blood ApoM-S1P complex correlates with olfactory dysfunction and LV enlargement in early AD patients. | Nature Communications

Fig. 6: Decrease of blood ApoM-S1P complex correlates with olfactory dysfunction and LV enlargement in early AD patients.

From: HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease

Fig. 6

a, b Levels of ApoM (a) and S1P (b) within HDL from PD patients (Normal, n = 21; PD, n = 20). c, d Levels of ApoM (c) and S1P (d) within HDL from AD patients (Normal, n = 27; MCI due to AD, n = 30; Early AD, n = 25). e Correlation between S1P levels within HDL and CC-SIT scores (Normal, n = 25; Early AD, n = 21). Intercepts and 95 % confidence intervals are indicated in the graphs. f Correlation between S1P levels within HDL and ventricular scores (Normal, n = 25; Early AD, n = 25). Intercepts and 95 % confidence intervals are indicated in the graphs. a, b Two-tailed student’s t test. c, d One-way analysis of variance, Tukey’s post hoc test. e, f two-tailed simple linear regression; r, Pearson correlation coefficient. Source data are provided as a Source Data file.

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