Table 1 Rapid and sustained gene responses in the gut (52 genes)
From: New molecular components of high and low affinity iron import systems in Drosophila
Upregulated (14 genes) | ||||||
|---|---|---|---|---|---|---|
Name | Description | Reported link to metal/iron? | 4 h | 8 h | 12 h | 16 h |
MtnB | Metallothionein | Yes | 13.6 | 3.6 | 10.7 | 3.0 |
CG10505 | ABC transporter | Yes (homolog of yeast cadmium factor) | 13.0 | 1.6 | 6.1 | 2.5 |
CG7763 | Lectin fold / carbohydrate binding | No | 11.2 | 2.1 | 5.2 | 3.5 |
galla-1 | Fe-S cluster biosynthesis | Yes | 7.6 | 4.4 | 4.8 | 2.5 |
Drip | Aquaporin family | Some data links Aquaporin-4 (Drip ortholog) to metal intoxication | 5.0 | 2.3 | 4.9 | 1.8 |
Zip99C | Zinc/iron permease | Yes | 4.4 | 2.5 | 3.6 | 1.9 |
Cyp6d2 | Cytochrome P450 6d2 | Yes (harbours heme) | 3.7 | 2.9 | 2.5 | 1.3 |
Fer1HCH | Ferritin 1 heavy chain | Yes (stores iron) | 3.1 | 4.0 | 7.5 | 4.5 |
GstD2 | Glutathione S transferase | Yes (induced by Zn and Cadmium) | 3.0 | 4.3 | 2.2 | 1.0 |
CG7720 | Sodium:iodide symporter | No | 2.8 | 2.2 | 3.1 | 1.1 |
rdog | ABC transporter | Yes (zinc detoxification) | 2.7 | 1.1 | 1.8 | 1.2 |
Fer2LCH | Ferritin 2 light chain | Yes (stores iron) | 2.4 | 3.5 | 8.9 | 4.0 |
Zip89B | Zinc/iron permease | Yes | 2.4 | 1.4 | 3.7 | 3.2 |
CG31288 | Possible ecdysteroid kinase | Yes (induced by Mn deficiency) | 2.0 | 1.6 | 1.4 | 1.2 |
Downregulated (38 genes) | ||||||
|---|---|---|---|---|---|---|
Fire (CG13078) | Ferric reductase | Yes | −45.1 | −7.1 | −40.8 | −78.1 |
Fire-like (CG13077) | Ferric reductase | Yes | −27.3 | −11.3 | −19.3 | −52.1 |
Firewood (CG5157) | Cytochrome b5 | Yes (predicted) | −22.1 | −5.4 | −7.7 | −15.2 |
CG14205 | acyltransferase | No | −8.0 | −2.0 | −1.8 | −1.4 |
CG5892 | acyltransferase | No | −7.5 | −2.6 | −1.8 | −3.3 |
MFS1 | Solute carrier family 17 | No | −5.6 | −2.2 | −1.3 | −1.7 |
Adh | Alcohol dehydrogenase | No | −5.2 | −2.4 | −1.2 | −1.3 |
Mvl | divalent metal ion transporter | Yes, DMT1 homolog | −4.5 | −2.3 | −2.1 | −3.3 |
CG9416 | Metallopeptidase | Yes (zinc ion binding) | −4.3 | −2.1 | −1.1 | −2.1 |
CG11576 | Solute carrier family 52 | No | −4.0 | −1.9 | −1.8 | −2.7 |
alpha-Est2 | Carboxylesterase | No | −4.0 | −2.8 | −1.3 | −1.3 |
mfrn | Mitochondrial iron import | Yes | −4.0 | −1.6 | −1.1 | −2.4 |
CG13893 | Phospholipid transport | No | −3.2 | −2.0 | −1.1 | −1.1 |
Ndae1 | Solute carrier family 4 | No | −3.2 | −1.7 | −1.0 | −1.2 |
regucalcin | CG1803 | No | −3.1 | −2.5 | −1.3 | −1.1 |
CG2543 | Folylpolyglutamate synthetase | No | −3.1 | −1.3 | −1.1 | −1.7 |
Cyp311a1 | Cytochrome P450 | Yes (heme-binding) | −2.9 | −2.8 | −1.3 | −1.1 |
CG18179 | peptidase | No | −2.8 | −5.4 | −3.1 | −4.6 |
CG10623 | Methionine synthesis | Yes (zinc ion binding) | −2.8 | −1.6 | −1.2 | −1.3 |
CG7589 | Secretory chloride channel | No | −2.7 | −2.1 | −1.3 | −1.6 |
CG6295 | Triacylglycerol lipase | No | −2.7 | −2.7 | −1.0 | −1.5 |
Spec2 | small GTPase binding | No | −2.5 | −2.3 | −1.1 | −1.7 |
Mal-A8 | Solute carrier family 3 | No | −2.5 | −3.2 | −1.2 | −1.2 |
CG1532 | Glyoxalase | No | −2.5 | −2.2 | −1.5 | −1.8 |
Sod3 | Superoxide dismutase | Yes (copper/zinc-binding domain) | −2.4 | −2.1 | −1.4 | −1.8 |
CG11594 | FGGY carbohydrate kinase | No | −2.4 | −1.7 | −1.0 | −1.1 |
CG5789 | ABC transporter-like | No | −2.3 | −1.4 | −1.2 | −1.8 |
AcCoAS | acetyl-CoA ligase | No | −2.2 | −1.7 | −1.1 | −2.0 |
CG34112 | No data | No | −2.2 | −1.8 | −1.1 | −1.0 |
CG10738 | CG10738 | Yes (heme NO binding associated) | −2.2 | −2.3 | −1.0 | −1.2 |
CG8839 | Fatty acid catabolism | No | −2.2 | −1.7 | −1.0 | −1.1 |
Jon99Fii | endopeptidase | No | −2.1 | −1.9 | −1.5 | −1.3 |
CG7470 | Glutamate 5-kinase | No | −2.1 | −1.6 | −1.1 | −1.4 |
CG15773 | No data | No | −2.1 | −2.4 | −1.1 | −1.2 |
CG17119 | Amino acid transporter | No | −2.0 | −1.6 | −1.1 | −1.2 |
CG8080 | NAD+ kinase | No | −2.0 | −1.6 | −1.0 | −1.0 |
CG13654 | No data | No | −2.0 | −2.4 | −1.1 | −1.5 |
CG33056 | Purine metabolism | No | −2.0 | −1.3 | −1.0 | −1.7 |
