Fig. 1: Fabrication of surface-engineered mPOC/HA implants. | Nature Communications

Fig. 1: Fabrication of surface-engineered mPOC/HA implants.

From: Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome

Fig. 1

a Illustration shows the combination of UV lithography and contact printing to fabricate free-standing mPOC/HA micropillars. b SEM image shows the micropillar structures made of mPOC/HA. c Optical microscope image and d cross-section analysis of mPOC/HA micropillars. e Surface scanning of flat and micropillar implants by AFM. f Surface roughness of flat and micropillar implants. N.S., no significant difference, n = 3 biological replicates. g Degradation test and h calcium release of flat and micropillar mPOC/HA implants. N.S., no significant difference, n = 4 biological replicates, insert plot shows the initial release of calcium within 24 h. i. Representative images of flat and micropillar implants at different time points after accelerated degradation. Data are presented as mean ± SD. Values from two groups were compared using a non-paired Student’s t-test (two-sided). Source data is provided as a Source Data file.

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