Fig. 5: mPOC/HA micropillar implant promotes bone regeneration in vivo. | Nature Communications

Fig. 5: mPOC/HA micropillar implant promotes bone regeneration in vivo.

From: Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome

Fig. 5

a Image shows implantation of hMSC seeded flat and micropillar mPOC/HA scaffolds. b Staining images of nuclei (green) and F-actin (red) of cells on the implants. c Representative μCT images of a typical animal implanted with hMSC-seeded flat (left) and micropillar (right) scaffolds at 12-weeks post-surgery. d Regenerated bone volume in the defect region (n  =  5 animals). e Trichrome staining of the defect tissue treated with flat and micropillar implants. f Average thickness of regenerated tissues with implantation of flat and micropillar scaffolds (n  =  5 animals). IHC staining of osteogenic marker, g OPN and h. OCN, in regenerated tissues with flat and micropillar implants. Data are presented as mean ± SD. Values from two groups were compared using non-paired Student’s t-test (two-sided). Source data is provided as a Source Data file.

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