Fig. 2: Mutation burden of virus-positive and virus-negative tumors in 9 cancers.

A Counts of somatic nonsynonymous mutations in virus-positive and virus-negative tumors in the same cancers. Data are presented as median values with interquartile range (25th–75th percentile). Actual median values for virus-negative and positive samples in the shown cancer types are PCNSL: 6 and 1, cHL (targeted): 10 and 4, cHL (WES): 126.5 and 65, cHL (WGS): 132 and 69, BL: 32 and 46, PBL: 9.5 and 4, GC: 117.5 and 86, CC: 279 and 68, HNSCC: 108 and 62.5, MCC: 22 and 7, HCC: 74 and 90.5. P-values are calculated by a two-sided Wilcoxon rank-sum test. B Log₂(fold change) of average number of somatic nonsynonymous mutations (all genes: dark blue, driver genes: light blue) in virus-negative tumors compared to virus-positive tumors. PCNSL (n = 58), CC (n = 172), MCC (n = 71), GC (n = 436), PBL (n = 51), cHL (target, n = 293; WES, n = 69; WGS, n = 24), HNSCC (n = 487), BL (n = 91 for all genes; 68 EBV-positive eBL, 6 EBV-negative eBL, 3 EBV-positive sBL, 14 EBV-negative sBL), BL (n = 120 for driver genes) and HCC (n = 190). GC, gastric cancer; HCC, hepatocellular carcinoma; cHL, classical hodgkin lymphoma; HNSCC, head and neck squamous cell carcinoma; MCC, Merkel cell carcinoma; PBL, plasmablastic lymphoma; PCNSL, primary central nervous system lymphoma; CC, cervical cancer; BL, Burkitt lymphoma. Data are presented as log₂(fold change) with error bars indicating 95% confidence intervals. Source data are provided as a Source Data file.