Fig. 4: FOXO4-DRI directly binds to p53TAD. | Nature Communications

Fig. 4: FOXO4-DRI directly binds to p53TAD.

From: The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

Fig. 4

a Sequence of FOXO4-DRI. b 1H,15N HSQC spectra of 15N-labeled p531–94 in the absence (black) or presence of one stoichiometric equivalent of FOXO4-DRI (orange) and corresponding CSPs. c 1H,15N HSQC spectra of 15N-labeled p53TAD2 in the absence (black) or presence of one stoichiometric equivalent of FOXO4-DRI (orange). d 1H,15N HSQC spectra of 15N-labeled FOXO4-LRI in the absence (black) or presence of one stoichiometric equivalent of D-p53TAD2 (blue) and corresponding CSPs.

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