Fig. 6: Phosphorylation of p53TAD2 enhances its affinity for FOXO4FH and FOXO4-DRI. | Nature Communications

Fig. 6: Phosphorylation of p53TAD2 enhances its affinity for FOXO4FH and FOXO4-DRI.

From: The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

Fig. 6

a Overlay of 1H,15N HSQC spectra of 15N-labeled FOXO4FH in the absence (black) or presence of one stoichiometric equivalent of p53TAD2 (blue) or p53TAD2pS46 (pink). b Overlay of 1H,15N HSQC spectra of 15N-labeled FOXO4FH in absence (black) or presence of one stoichiometric equivalent of p53TAD2 (blue) or p53TAD2pT55 (violet). c Overlay of 1H,15N HSQC spectra of 15N-labeled FOXO4-LRI in absence (black) or presence of two stoichiometric equivalent of p53TAD2 (bleu), p53TAD2pS46 (pink) or p53TAD2pT55 (violet) and associated CSPs.

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