Fig. 2: Immunodominant proteins in CHIKV proteome recognized by CD4+ T cells. | Nature Communications

Fig. 2: Immunodominant proteins in CHIKV proteome recognized by CD4+ T cells.

From: Identification of immunogenic and cross-reactive chikungunya virus epitopes for CD4+ T cells in chronic chikungunya disease

Fig. 2

a Frequency (%) of epitopes detected per CHIKV protein. n refers to the number of total epitopes identified. b The magnitude (SFC/106 PBMCs) of positive response to each epitope in the entire CHIKV proteome. The percentage shows the percent of the overall magnitude of responses elicited by each protein. The heatmap under the graph and the heatmap legend of the side of the graph indicates the number of donors that recognize each epitope, ranging from 0–9 donors. c The lower bound of the 95% confidence interval of response frequency of each epitope plotted for the non-structural (top) and structural polyprotein (bottom). Each overlapping peptide was mapped to the sequence of the representative isolate, and the response frequency for each residue was calculated using the ImmunomeBrowser tool in IEDB-AR. The lower bound of the confidence interval was plotted for each residue to visualize regions with dominant responses. The dotted line indicates the threshold of positivity (0.2). The highlighted regions depict the residue number that reaches the threshold of positivity and the associated peptide sequences.

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