Fig. 3: The dopamine (DA) detection performance of the NeuroRevive-FlexChip. | Nature Communications

Fig. 3: The dopamine (DA) detection performance of the NeuroRevive-FlexChip.

From: Integrated dopamine sensing and 40 Hz hippocampal stimulation improves cognitive performance in Alzheimer’s mouse models

Fig. 3

a Cyclic voltammograms of the NeuroRevive-FlexChip working micro-electrode in PBS and 200 μM DA solution (−0.3 ~ 0.6 V, 100 mV/s). b Calibration curve of the DA detection micro-electrode (10 nM~80 μM) (The red dashed box indicates the DA detection range of 10 nM~2 μM, which is magnified in Fig. 3c.). c Local calibration curve of the DA detection microelectrode (10 nM~2 μM). d Current response fitting curves at different DA concentrations (0 ~ 10 μM: y = 0.07171x + 1.52608, R² = 0.973; 10 ~ 80 μM: y = 0.03104x + 2.06087, R² = 0.994) (n = 3 independent detection sites per group; data are presented as mean ± s.d.). e Current response curves under the interference of UA, LA, AA, 5-HT. f Comparative current responses under interference (n = 3 independent detection sites per group; data are presented as mean ± s.d.). Statistical significance was assessed by unpaired two-tailed Student’s t-tests. ns, not significant (p ≥ 0.05); *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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