Fig. 2: Biochemical properties of the chosen protein targets.
a Three-dimensional structure of five different protein targets (PT) used during selection screening: aldolase (PT1, PDB identification code 1QO5), streptavidin (PT2, PDB identification code 7EK8), carbapenemase GES-5 (PT3, PDB identification code 6TS9), carbonic anhydrase (PT4, PDB identification code 1VE9), and α-chymotrypsin (PT5, PDB identification code 6DI9). The overall target secondary structure is shown as cartoon and coloured by secondary structure (α-helices = firebrick, β-sheet = sky-blue, random coil = white). Proteins are ordered according to their molecular weight (MW), from largest (left) to smallest (right). b Heat map showing the amino acid identity among different PTs. The intensity of the colour correlates with the identity percentage. High and low identities are shown in dark blue and white, respectively. c From left to right, bar chart showing the distribution of the MW, solvent accessible surface area (ASA), number of pockets74, and surface/volume ratio of each PT. d Columns graph reporting the percentage of secondary structure content (α-helices = firebrick, β-sheet = sky blue, random coil = light grey) for each PT tested. Data for b–d are provided as Source data.
