Fig. 5: Model for DBHS mediated telomerase recruitment to telomeres.
From: NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere
The DBHS proteins (NONO, SFPQ, PSPC1) dimerize with each other to facilitate telomerase trafficking out of Cajal bodies by interacting with the hTR telomerase subunit. The DBHS proteins then facilitate telomerase recruitment to the telomere, potentially stabilizing the interaction through polymerization. In addition to recruitment, PSPC1 is also involved in Cajal body formation through coilin expression (1), while NONO and SFPQ play cell line specific roles in reducing telomerase assembly with hTR (2) and hTR stability (3).
