Table 3 Spearman correlation coefficients between TFI (2D) and MFI (2D), TFI (3D) and MFI (3D) in WT and ATG7 KO PIP-FUCCI cell lines

From: Evaluating cell cycle- and autophagy-associated cellular accumulation of lipid-based nanoparticles

 

WT PIP-FUCCI

ATG7 KO PIP-FUCCI

MFI (2D) of DiD-LIP

MFI (2D) of DiD-LNP

TFI (3D) of DiD-LIP

TFI (3D) of DiD-LNP

MFI (2D) of DiD-LIP

MFI (2D) of DiD-LNP

TFI (3D) of DiD-LIP

TFI (3D) of DiD-LNP

TFI (2D) of DiD-LIP

0.711 (p < 0.0001)

/

/

/

0.699 (p < 0.0001)

/

/

/

MFI (3D) of DiD-LIP

/

/

0.495 (p < 0.0001)

/

/

/

0.546 (p < 0.0001)

/

TFI (2D) of DiD-LNP

/

0.918 (p < 0.0001)

/

/

/

0.856 (p < 0.0001)

/

/

MFI (3D) of DiD-LNP

/

/

/

0.871 (p < 0.0001)

/

/

/

0.791 (p < 0.0001)

  1. TFI Total fluorescence intensity, MFI Mean fluorescence intensity, DiD-LIP DiD-labeled liposomes (at a dose equivalent to 5 μg/mL DOX), DiD-LNP DiD-labeled lipid nanoparticles (at a dose equivalent to 6 μg/mL mRNA), 2D Two-dimensional level, 3D Three-dimensional level. The level of significance was set at p < 0.05. Source data are provided as a Source Data file.