Fig. 4: Rapid expansion of cilta-cel CAR T is associated with a CAR-specific shift towards effector-memory T cell subtypes. | Nature Communications

Fig. 4: Rapid expansion of cilta-cel CAR T is associated with a CAR-specific shift towards effector-memory T cell subtypes.

From: Immune correlates of anti-BCMA CAR-T products idecabtagene vicleucel and ciltacabtagene autoleucel in a real-world cohort of patients with multiple myeloma

Fig. 4

A We investigated the distribution of certain memory subtypes (CM = of central memory; TSCM = T memory stem cells; EM = effector-memory; EMRA = terminal effector memory) the different CAR T products as defined by the expression of certain memory markers as indicated. All 4 T cell memory subtypes were investigated in both patient groups (blue = cilta-cel, N = 23; red = ide-cel, N = 16) at the time of the individual CAR T peak. Results are shown for (B) CD4+, (C) CD8+, (D) CD4+CD8+ CAR T cells and for (E) CD4+ non-CAR T from the same patient/timepoint. Bar graphs show percentages of the given memory subtype out of all CD4+, CD8+, CD4+CD8+ CAR T cells or CD4+ non-CAR T in patients post cilta-cel (blue, N = 23) or ide-cel (red, N = 16), respectively. Bar graphs indicate median values with 95% confidence intervals (CI). Statistical differences between groups were calculated using a two-sided Mann-Whitney U test. Source data are provided as a Source Data file.

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