Fig. 9: Schematic representation of the role of PI3Kγ in the trafficking of CD8+ T cells between lymphoid and non-lymphoid tissues in hypertension. | Nature Communications

Fig. 9: Schematic representation of the role of PI3Kγ in the trafficking of CD8+ T cells between lymphoid and non-lymphoid tissues in hypertension.

From: PI3Kγ signaling controls trafficking of CD8+ T cells between lymphoid and non-lymphoid organs and drives hypertension in a murine model

Fig. 9

Activation of PI3Kγ in CD8+ T cells promotes maturation of effector functions and induces hypertension through enhanced myogenic tone of resistance mesenteric arteries. In kidneys, CD8+ T cells with activated PI3Kγ infiltrate and contribute to impaired renal function in hypertension. Figure created in BioRender. Perrotta, M. (2025) https://BioRender.com/t342v4n.

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