Fig. 1: PADI4 stimulates HIV-1 transcription after cell stimulation in cells from viremic people with HIV-1.
From: PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription
a Extracellular HIV-1 RNA with PMAi and GSK484 treatments from entire cohort (n = 26, study participant characteristics in Table S1). b Intracellular cell-associated HIV-1 RNA in the cohort stratified into in viremic (n = 9) and long-term ART-suppressed (n = 14) groups. c Intact HIV-1 proviral reservoir from the viremic (n = 9) and long-term ART-suppressed (n = 10) groups measured by IPDA. HIV-1 5´LTR RNA (d) and Tat-Rev (e) quantified in viremic (n = 11) and long-term ART-suppressed groups (n = 15). f PADI4 expression in the viremic (n = 11) and long-term ART-suppressed (n = 14) normalized to RPP30. The number of independent study participants included in each panel is denoted by n. All statistical tests shown are two-sided Wilcoxon matched-pairs signed rank test, exact p-values are indicated. Source data are provided as a Source Data file.
