Fig. 4: Genome-wide H3cit levels are stable at promoters in 5A8 with HIV-1 preferentially integrating into H3cit chromatin.

a CUT&Tag peak width profile. b Relative enrichment of peaks in genic and non-genic regions. c Metagene plot for DMSO-treated 5A8 samples. d ChromHMM analysis showing similarity between chromatin marks. e Quantification of H3cit mapped onto known proviral integration sites with corresponding proviral activation, H3cit values over 467 latent, 714 productive, 68 reactivatable, 843 non I.S randomly selected genomic positions are plotted. The box plots indicate median (middle line), 25th, 75th percentile (box), as well as minimum and maximum values (whiskers). f Metagene plot with a gene set (146 genes) regulated by T cell activation (“GSE13738 Resting vs TCR activated CD4⁺ T cell”). The shaded area shows the standard error of the data. Source data are provided as a Source Data file.