Fig. 3: Immunoreactivity of Opisthorchis viverrini recombinant proteins printed on immunochromatography tests (ICTs) for the serodiagnosis of opisthorchiasis, clonorchiasis and opisthorchiasis-associated cholangiocarcinoma (CCA). | Nature Communications

Fig. 3: Immunoreactivity of Opisthorchis viverrini recombinant proteins printed on immunochromatography tests (ICTs) for the serodiagnosis of opisthorchiasis, clonorchiasis and opisthorchiasis-associated cholangiocarcinoma (CCA).

From: Immunomics-guided biomarker discovery for human liver fluke infection and infection-associated cholangiocarcinoma

Fig. 3

A positive ICT reaction based upon visual assessment was afforded to a protein if a score of equal to or greater than 0.5–1 was attained; each protein has a defined cut-off as described in Supplementary Table 3. Digital scorecard (left) and ICT strips (right) with scores ranging from 0 to 4 are shown (a). C = Control band, T = test band. The IgG (b) and IgG4 (c) positivity rates (%) are shown for the 5 candidate antigens with successful ICT formulations. Ov-: 50 healthy uninfected controls from Thailand (endemic and non-endemic); Ov + : 114 O. viverrini infected subjects with known EPG (Thailand and Laos); Cs + : 50 Clonorchis sinensis infected subjects; CCA: 50 CCA patients where the causative agent was suspected to be O. viverrini infection.

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