Fig. 3: A high-fiber diet mimics the transcriptional patterns of CR in 2-month-old male mice.
From: A high-fiber diet mimics aging-related signatures of caloric restriction in mammals
a Heatmap of CR-regulated genes in liver (n = 6 mice per group; FDR < 0.05). b Bar chart showing the number of DEGs across five feeding conditions compared to the RD group. c Spearman correlation plots showing significant correlation in gene expression FC between the CR and CF30m groups, compared to RD. Top 20 GO terms enriched in genes upregulated (d) or downregulated (e) by CF30m. f Expression of representative lifespan-related genes known to shorten lifespan when inhibited. Box-and-whisker plots (minimum, 25th percentile, median, 75th percentile, maximum), n = 6 biologically independent samples per group. g Expression of representative genes associated with immune or inflammatory responses. Box-and-whisker plots (minimum, 25th percentile, median, 75th percentile, maximum), n = 6 mice per group. Data are presented as mean ± SEM, n = 6 mice per group. Statistical significance was determined by one-way ANOVA (Dunnett’s test). *P < 0.05, **P < 0.01, ***P < 0.001.
