Table 1 Demographics and pathological scores of donors in the study cohort
Parameters | Control | iLBD | PD | p value |
|---|---|---|---|---|
N (tot = 69) | 10 | 32 | 27 | |
Sex F/M (%F) | 4/6 (40%) | 20/12҂ (63%) | 7/20 (26%) | 0.015* |
Age at death years; mean [range] | 76 [67, 85] | 85##, ҂҂ [66, 96] | 77 [56, 92] | < 0.001*** |
Disease duration years; mean [range] | – | – | 16 [8, 28] | |
PMD h:min Mean [range] | 6:35 [3:50, 8:45] | 6:35 [4:25, 11:45] | 6:30 [3:30, 10:10] | 0.3 |
Braak α-syn stage10 N (%) | – | |||
0 | 10 (100%) | 0 (0%) | 0 (0%) | |
1 | 0 (0%) | 10 (31%) | 0 (0%) | |
2 | 0 (0%) | 3 (9.4%) | 0 (0%) | |
3 | 0 (0%) | 9 (28%) | 0 (0%) | |
4 | 0 (0%) | 7 (22%) | 5 (19%) | |
5 | 0 (0%) | 2 (6.3%) | 12 (44%) | |
6 | 0 (0%) | 1 (3.1%) | 10 (37%) | |
Braak NFT stage70 N (%) | 0.14 | |||
B0 | 2 (20%) | 1 (3.1%) | 1 (3.7%) | |
B1 | 5 (50%) | 21 (66%) | 22 (81%) | |
B2 | 3 (30%) | 10 (31%) | 4 (15%) | |
B3 | 0 (0%) | 0 (0%) | 0 (0%) | |
Thal phase70 N (%) | 0.3 | |||
A0 | 2 (20%) | 5 (16%) | 6 (22%) | |
A1 | 8 (80%) | 19 (59%) | 12 (44%) | |
A2 | 0 (0%) | 7 (22%) | 9 (33%) | |
A3 | 0 (0%) | 1 (3.1%) | 0 (0%) |
