Fig. 4: Size-dependent CNA co-occurrence patterns and total CNA burden predict meningioma outcomes. | Nature Communications

Fig. 4: Size-dependent CNA co-occurrence patterns and total CNA burden predict meningioma outcomes.

From: Pan-cancer copy number analysis identifies optimized size thresholds and co-occurrence models for individualized risk stratification

Fig. 4

a Kaplan-Meier curves comparing meningioma LFFR according to individual CNAs versus co-occurrent CNA pairs identified as the most important predictors of clinical outcomes in LASSO Cox models from Supplementary Fig. 6b using chromosome-specific CNA size thresholds. Log-rank tests. n = 365 meningiomas. b Heatmap showing unsupervised hierarchical clustering of individual CNAs according to the total number of CNAs per meningioma. CNAs were defined using optimal size thresholds for LFFR or OS. Bar plots on the right side of each heatmap measure the total number of co-occurrent pairs including each of the CNAs, across all samples containing that CNA. c, Kaplan-Meier curves showing meningioma LFFR or OS according to CNA burden. Log-rank tests. n = 565 meningiomas. Source data are provided as a Source Data file.

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