Fig. 5: Pan-cancer analyses reveal chromosome-specific size-dependent CNA co-occurrence risk-stratification patterns. | Nature Communications

Fig. 5: Pan-cancer analyses reveal chromosome-specific size-dependent CNA co-occurrence risk-stratification patterns.

From: Pan-cancer copy number analysis identifies optimized size thresholds and co-occurrence models for individualized risk stratification

Fig. 5

a Heatmap showing chromosome-specific size-dependent CNAs across TCGA cancer types. Size-dependent CNAs were defined as having (1) a univariate Cox AUC for either PFS or OS of at least 0.60, (2) a standard deviation for AUC across CNA size thresholds of at least 0.01, and (3) presence in at least 2.5% of samples for a given TCGA cancer type. A full list of optimal size thresholds and AUCs are provided in Supplementary Data 8. b Selected Kaplan-Meier curves showing prognostic co-occurrent CNA pairs for PFS or OS identified using LASSO Cox models of size-dependent CNAs for TGCA cancer types. Log-rank tests. n = 426 COAD, 182 ESCA, 571 GBM, 283 KIRP, 510 LGG, 367 LIHC, 500 LUAD, and 87 MESO. Source data are provided as a Source Data file.

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