Fig. 2: Structure-property relationship studies of the pyrazolopyridine series of EV-D68 2C inhibitors.
From: A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis
a Antiviral EC50 values were determined in the CPE assay with EV-D68 US/MO/14-18947 in RD cells. Cytotoxicity CC50 values were determined using the neutral red uptake method in RD cells. The results are the mean ± standard deviation (SD) of two independent experiments with three repeats in each experiment. *The antiviral activity EC50 values of Jun5532 and Jun5253 were reported earlier31. SI selectivity index. b Antiviral activity of selected 2C inhibitors against EV-A71 Tainan strain in plaque assay. c Antiviral activity of selected 2C inhibitors against CVB3 Nancy strain in plaque assay. The EC50 values in the plaque assay are the mean ± SD of two biological replicates. Source data are provided as a Source Data file.
