Fig. 3: In vivo pharmacokinetic profiling of EV-D68 2C inhibitors in BALB/c mice.
From: A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis
a In vivo clearance of Jun5532, Jun10241, and Jun6504 in female BALB/c mice (n = 5) after i.p. injection at 50 mg/kg. Error bars denote mean ± SD of five biological replicates. b In vivo clearance of Jun6962 and Jun9351 in female BALB/c mice (n = 5) after i.p. injection at 30 mg/kg. Error bars denote mean ± SD of five biological replicates. c Pharmacokinetic parameters. The values represent mean ± SD of five biological replicates. Adult female BALB/c mice were given a single i.p. injection at either 50 or 30 mg/kg. Blood samples were collected up to 12 h after administration of the compound. The plasma concentrations of inhibitors and the internal standard were analyzed by LC–MS/MS. Source data are provided as a Source Data file.
