Fig. 4: Characterization of exploration-exploitation trade-off for PBMC media blending case. | Nature Communications

Fig. 4: Characterization of exploration-exploitation trade-off for PBMC media blending case.

From: Accelerating cell culture media development using Bayesian optimization-based iterative experimental design

Fig. 4

A Evolution of cell viability of the experiments planned in the different iterations indicated as boxplots of the biological triplicate data (with some experiments having up to five replicates). The box spans between first and third quartile encompassing a line for the median. The whiskers extend to the farthest data point that falls within 1.5 times the interquartile range. Points outside this range is indicated as fliers. The progressively increasing shades of red correspond to the increasing iteration number. B Evolution of the location of the experiments in the feasible design space during the different iterations represented in a pairwise plot of the design factors. C Composition of the different media blends tested in experiments planned in the different iterations. Source data are provided in Source Data.xlsx file.

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