Fig. 3: Resistome variation and taxonomic composition.
From: Variation and prognostic potential of the gut antibiotic resistome in the FINRISK 2002 cohort
a Resistome composition: relative abundance of the 10 most abundant ARG classes in the FINRISK cohort (N = 7095 participants). b Bacterial species diversity and resistome (ARG) diversity (Shannon index; Pearson, P < 10−3, r = 0.32, 95% confidence interval, 0.30–0.34, N = 7095 participants). c Enrichment of high-ARG load participants (>458 RPKM) as a function of enterosignature abundance (ES) (B0: not detected; B1–B4: 25% abundance quartiles, N = 7095 participants); each enterosignature (ES) represents a sub-community of co-varying bacterial genera (Supplementary Fig. 5). ES-Bact is characterized by Bacteroides, ES-Firm by Firmicutes, ES-Prev by Prevotella, ES-Bifi by Bifidobacteria, ES-Esch by Escheria. The estimated prevalence of high-ARG individuals within each abundance bin is shown as points with 95% credible intervals represented by bars (probabilistic Bernoulli model, see “Methods” section). The dashed line indicates the expected prevalence of the high-ARG individuals in the entire study population (10%). d Associations between the abundance of each ES and bacterial species diversity, resistome diversity, total ARG load, and load of the five most dominant ARG classes (two-sided Kendall’s Tau with FDR correction; Supplementary Table 5). All associations are significant (P < 0.05), except Beta-lactam in ES-Bact and ARG load in ES-Bifi. Abbreviations: MLSB: “Macrolide, Lincosamide, Streptogramin B”; MATQAR: “Macrolide, Aminoglycoside, Tetracycline, Quinolone, Amphenicol, Rifamycin”. e Phylogenetic relatedness among the most prevalent bacterial genera in the FINRISK cohort and their association with the most prevalent ARGs. Node size indicates the total number of ARGs found in each genus according to the BLAST nr database; the colors indicate a match between each genus and the ARGs.
