Fig. 2: Benchmarking SigXTalk against representative methods.
From: Dissecting crosstalk induced by cell-cell communication using single-cell transcriptomic data
a The workflow of the benchmark using simulated data. b Boxplots for the AUROC of SigXTalk and 12 representative methods on 10 independent tests on the simulated data. c Boxplots for the AUPRC of SigXTalk and 12 representative methods on 10 independent tests on the simulated data. d The workflow of the benchmark using real data. e Boxplots for SigXTalk (42 identified receptor pairs), NicheNet-comp (366 identified receptor pairs), NicheNet-db (119 identified receptor pairs) and CytoTalk (0 identified receptor pairs), represented by the coverage, p-value of two-sided Fisher’s exact test (shown in a log10 scale), and p-value of Chi-square test (shown in a log10 scale) for each receptor pair. Boxplot elements: center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range; points, outliers. Source data are provided as a Source Data file.
